tag:blogger.com,1999:blog-75473566213844872592009-12-10T08:49:49.293-05:00Prostate cancer topics, links and more. Now at <a href="http://palpable-prostate.blogspot.com/2008/02/contents.html">100+ posts!</a><br>The Palpable Prostatehttp://www.blogger.com/profile/16142459096123501053noreply@blogger.comBlogger123125tag:blogger.com,1999:blog-7547356621384487259.post-8387685731371809842009-11-29T08:18:00.007-05:002009-11-29T08:49:28.812-05:00

Nov 18/09. In Choosing a Surgeon - Part I. Considerations, Choosing a Surgeon - Part I. Considerations we added: Savage and Vickers determined the typical annual radical prostatectomy caseloads of surgeons in the United States by analyzing "data from 2 independent data sets for 2005, that of a nationally representative sample (Nationwide Inpatient Sample) and a complete record of all hospital

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Oct 26/09. Added AUA/ASCO AR5 Inhibitors 2009 guideline to Guidelines-US line of the Links box in the right margin: [AUA/ASCO AR5 Inhibitors 2009]Oct 26/09. Added AUA PSA guidelines for 2009 on the Guidelines-US line of the Links box in the right margin: [AUA PSA 2009]Oct 11/09. Added [Rachlis] blog to the blog line of the Links box in the right margin. Writer is a Canadian physician who

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Sep 28, 2009. In PSA Screening and Early Detection - Part 5. More Diagnostic Testing Concepts we added another example: A 2009 meta analysis of PSA testing [PMID: 1974436] summarized various studies on PSA accuracy with the following table: Study Year No TP FP FN TN Sensitivity Specificity 1 Aragona 2005 3171 1073 1695 98 305 0.92 0.15 2

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Aug 14. On the Case Histories page we added: PCA International has 6 videos by medical personnel and patients here.Aug 14. In How Healthy Men Can Reduce Their Risk we added: A 2009 review of prostate cancer screening and prevention by Eric Klein (papers) of the Cleveland Clinic is available here: [Full Text] [PMID: 19652036].Aug 14. In How Healthy Men Can Reduce Their Risk we added: Eric Klein

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July 24/09. In Biochemical PSA Recurrence we added: Local Recurrence vs. Systemic Disease. Local recurrence refers to rising PSA without further spread of the disease (i.e. without metastases). If the disease has spread then it is referred to as systemic. At the 2009 ASCO meeting John Hopkins researchers reported on a 25 year follow up to patients who had surgery and subsequent recurrence.

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June 16/09.Added to Free Monthly Prostate Cancer Magazines and Journals these lists of free medical journals (not necessarily in the field of urology):NHS (UK)http://www.library.nhs.uk/Default.aspxNIH - Pubmed Central (US)http://www.pubmedcentral.nih.gov/fprender.fcgiBiomed Centralhttp://www.biomedcentral.com/browse/journalsJune 16/09. On the Case Histories page we added: surgery takes effect

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May 25/09. On the Calculators page we added: Castrate Resistant Prostate Cancer. This calculator answers the question of whether the patient has castrate resistant prostate cancer and what the optimal treatment is. In association with this calculator readers may wish to view this presentation by Nicholas Vogelzang (papers).May 10/09. In Advice to the Newly Diagnosed we added: Major medical

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Apr 23/09/. In ED After Prostatectomy. Part 2 - Rehabilitation we add a reference to this Feb. 2009 paper in the Canadian Urological Association Journal: [PMID: 19293974] [Full Text] which reviews rehabilitation.Apr 23/09. In Choosing a Surgeon - Part I. Considerations, Choosing a Surgeon - Part I. Considerations we added: Different primary care physicians have different approaches toward PSA

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Mar 27/09. In Screening and Early Protection. Part 3 - Current Environment we added: In response to two studies on PSA testing the president of the AUA stated: "The American Urological Association has read with great interest the coverage surrounding the two studies about prostate-specific antigen (PSA) testing recently published in the New England Journal of Medicine, and is concerned about

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Feb 28. In How Healthy Men Can Reduce Their Risk we added: AR5 Inhibitors. ASCO and AUA issued the following guidelines on AR5 inhibitors in February 2009:Men who have a PSA with a score of 3.0 or below who already get yearly PSA tests, or expect to get a yearly PSA test, and show no signs of prostate cancer may benefit from talking with their doctor about the risks and benefits of a 5-ARI,

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Jan 31. In Advice to the Newly Diagnosed we added: Also see this January 2009 study [PMID: 19054189] and Medical New Today summary which found that for patients with Gleason Score 7 or less (59.1% of the patients) that survival was not substantially worse than men without prostate cancer.Jan 19. In the Historical Developments Dr. Donald Gleason, developer of the Gleason Score, dies Dec 28th.

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To wrap up 2008 there were over 40,000 page views of this blog this year. The 10 most visited pages on this blog (most visted first, second most visited second, etc.) were:The Palpable ProstateThe Palpable Prostate: Prostate Cancer Calculators The Palpable Prostate: Biochemical PSA RecurrenceThe Palpable Prostate: ED After Prostatectomy - Part 1. IntroductionThe Palpable Prostate: Yananow Place

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Nov 28. Added to the Treatments: line in the Links section to the right this link to Washington Post CyberKnife article: [CyberK]Nov 28. Added to the Medical/Uro line in the Links section to the right this link to [Medline+]Nov 28. Added the following information on the new HHS exercise and physical fitness guidelines on the Guidelines - US line in the Links section to the right: HHS Exercise (

The Palpable Prostatehttp://www.blogger.com/profile/16142459096123501053noreply@blogger.com0tag:blogger.com,1999:blog-7547356621384487259.post-72993442049235114332008-10-25T08:27:00.002-05:002008-10-27T17:03:11.978-05:00

Oct 23. In Questions to Ask Doctor added this link on generic questions not specifically relating to any particular disease but rather questions which relate to any disease.Oct 18. In ED After Prostatectomy. Part 2 - Rehabilitation we add: Pelvic floor or Kegel exercises have also found to be beneficial. See [PMID: 15527607] [Full Text] and particularly Box 1 of that paper where the exercises

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Sep 27. In PSA Screening and Early Detection Part 2 we add that the particular PSA Assay can affect the results of a PSA test: Standard PSA tests are usually standardized to the WHO 90:10 standard or standardized to the original Hybritech(R) standard. [PMID: 18801532]. If ones switches among tests using different standards then a significant difference may appear even if there is no real

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Aug 26. In PSA Screening and Early Detection - Part 3. Current Environment we add the following link to a comment by Catalona regarding the U.S. Preventive Services Task Force recommendations on PSA testing: A rebuttal to the task force recommendations by Dr. William Catalona appeared in the Washington Post [full text] on August 26, 2008 page A13.Aug 25. In WCRF/AICR Diet and Cancer Report we

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July 1/08. In PSA Screening and Early Detection - Part 2. Key Points on PSA we added this item: [PMID: 18267334] has even suggested that it may be necessary to lower the cutpoints used to assess the presence of prostate cancer in the obese.July 1. In Prostate Cancer Calculators we added this link to the info on subdivisions of the WHO BMI data.July 1. Added to Free Monthly Prostate Cancer

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[Updated April 24, 2009]Some of this material was previously part of Advice to the Newly Diagnosed but has been expanded and so placed here on a separate page.The Nature of Radiation RiskRadiation involves health risks which increase with (1) increasing dosage of radiation received and number of times that radiation was received, (2) youth, i.e. inversely with age -- the younger one is the

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June 1/08. In PSA Screening and Early Detection - Part 2 added: Thus for a given level of PSA a smaller prostate is associated with a higher likelihood of prostate cancer than a larger prostate. In particular a rule of thumb is that for each cubic centimeter (cc) of benign prostate tissue that 0.067 ng/ml of PSA will be produced. Thus for a prostate of 40cc one would expect a PSA of 40 x

The Palpable Prostatehttp://www.blogger.com/profile/16142459096123501053noreply@blogger.com0tag:blogger.com,1999:blog-7547356621384487259.post-29979232775225531222008-05-31T07:34:00.016-05:002008-06-24T09:06:52.897-05:00

May 1. In PSA Screening and Early Detection - Part 3. Current Environment we add a reference to an April Pros and Cons of Screening article: The pros and cons of PSA testing are discussed on pages 8 and 9 of William Ware, 2005. A debate on the screening between Dr. Catalona (pro) and Dr. Talcott (con) was featured at the 2006 AUA conference and is discussed Medscape (login required but free).

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April 2/08. In Lycopene, Selenium and Vitamin E in Combination we added: Dr. Marc Garnick (papers) of the Harvard Medical School has written a brief summary of the pros and cons of selenium here. There has been some speculation that selenium might hide rather than prevent prostate cancer.April 2/08. Added to Bradford Hill Criteria of Causation: Patient Confusion. Patients themselves may

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Mar 1/08. On the Case Histories page we have added: Bill Minnick had multiple cancers in addition to prostate cancer. He underwent both RT and HT and has created the endcancernow.org web site which is focused on his personal experience with a macrobiotic diet and cancer.March 1. In PSA Screening and Early Detection - Part 2 added reference to this 2008 review article on early vs. late

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Feb 1/08. In Choosing a Surgeon - Part 2. Finding a Surgeon we add: The PCRI site lists some doctors by speciality and name.Feb 1. In Prostate Cancer Calculators we added:There are two particularly comprehensive prostate cancer calculator sites. Their links are easy to remember since their links are nearly the same: http://www.nomogram.org (University of Montreal) and http://www.nomograms.org (

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The first post of the Palpable Prostate was published on February 11, 2007 making today the one year anniversary. This is also the 100th post. To make it easier to find material among that many posts this page contains the site Contents.Calculators & PrognosesProstate Cancer CalculatorsPSA Doubling Time (PSADT) - Part 1. Introduction &...PSA Doubling Time (PSADT) - Part 2. Calculating PS...PSA

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[Updated May 7, 2009]IntroductionIn this post we discuss theories of testosterone metabolism as it relates to prostate cancer. The research discussed here involves, in part, theories which, while based on scientific studies, still require additional investigation in order to establish their validity in a medical context. We will primarily rely on the four pathway model found in Endotext, an

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