tag:blogger.com,1999:blog-6780103924890350442.post-17084169872061240482008-06-30T22:08:00.000-07:002008-07-03T20:53:27.072-07:00I'm sure as a kid, your mother warned you over and over and over how dangerous running with sharp objects is...<br /><br />Or sharp pencils... Or knives... Or chopsticks...<br /><br />Or Lp(a)??! wtf??<br /><br /><br /><br /><br /><br /><br /><div align="center"><em><span style="font-size:85%;">Ben Harper and friends: THERE WILL BE LIGHT</span></em></div><div align="center"><em><span style="font-size:85%;">Rome Concert Live</span></em></div><div align="center"><em><span style="font-size:78%;"><object width="281" height="186" class="BLOG_video_class" id="BLOG_video-7f1da39ed4428da5" classid="clsid:D27CDB6E-AE6D-11cf-96B8-444553540000" codebase="http://download.macromedia.com/pub/shockwave/cabs/flash/swflash.cab#version=6,0,40,0"><param name="movie" value="http://www.blogger.com/img/videoplayer.swf?videoUrl=http%3A%2F%2Fvp.video.google.com%2Fvideodownload%3Fversion%3D0%26secureurl%3DqgAAAHfApvOOOB_WlESfHfM9b00ctQJyVaI4Arx7v4bDAp83CCKSvaxSMFrc80AMd7W1Ijh-jl5cGGjNVjO4Gu3kIUcm6scu0kBBFMZ7IFaN88F4xuQuC4nzAUSvr8rpXvJU753O_cqFcNUbZYGb8HiE14CnBDc65K7TqLjBRH8OtXP31EbCNmKGZFvuBGCdcWUhQNHQGiYHfveX4fI0xQziL53n1WE-TCm2AcSEICP4hLvP%26sigh%3D8Fo1pRdYOa3-5eZB1LSHqP3Fo9E%26begin%3D0%26len%3D86400000%26docid%3D0&amp;nogvlm=1&amp;thumbnailUrl=http%3A%2F%2Fvideo.google.com%2FThumbnailServer2%3Fapp%3Dblogger%26contentid%3D7f1da39ed4428da5%26offsetms%3D5000%26itag%3Dw320%26sigh%3DIG6r-40HIywaiDuFDdiCyb4xQD8&amp;messagesUrl=video.google.com%2FFlashUiStrings.xlb%3Fframe%3Dflashstrings%26hl%3Den"><param name="bgcolor" value="#FFFFFF"><embed width="281" height="186" src="http://www.blogger.com/img/videoplayer.swf?videoUrl=http%3A%2F%2Fvp.video.google.com%2Fvideodownload%3Fversion%3D0%26secureurl%3DqgAAAHfApvOOOB_WlESfHfM9b00ctQJyVaI4Arx7v4bDAp83CCKSvaxSMFrc80AMd7W1Ijh-jl5cGGjNVjO4Gu3kIUcm6scu0kBBFMZ7IFaN88F4xuQuC4nzAUSvr8rpXvJU753O_cqFcNUbZYGb8HiE14CnBDc65K7TqLjBRH8OtXP31EbCNmKGZFvuBGCdcWUhQNHQGiYHfveX4fI0xQziL53n1WE-TCm2AcSEICP4hLvP%26sigh%3D8Fo1pRdYOa3-5eZB1LSHqP3Fo9E%26begin%3D0%26len%3D86400000%26docid%3D0&amp;nogvlm=1&amp;thumbnailUrl=http%3A%2F%2Fvideo.google.com%2FThumbnailServer2%3Fapp%3Dblogger%26contentid%3D7f1da39ed4428da5%26offsetms%3D5000%26itag%3Dw320%26sigh%3DIG6r-40HIywaiDuFDdiCyb4xQD8&amp;messagesUrl=video.google.com%2FFlashUiStrings.xlb%3Fframe%3Dflashstrings%26hl%3Den" type="application/x-shockwave-flash"></embed></object></span></em></div><div align="center"><em><span style="font-size:85%;">Courtesy of Youtube.com</span></em></div><br /><br /><br /><br /><br /><div align="center"><span style="font-size:85%;">I wish we could live forever...<br /><br /></span></div><div align="center"><span style="font-size:85%;">Then melt into the sun</span></div><div align="center"><span style="font-size:85%;">Melt into the sun</span></div><div align="center"><span style="font-size:85%;"></span></div><div align="center"><span style="font-size:85%;">Time is gonna change you</span></div><div align="center"><span style="font-size:85%;">Once it gets you on the run</span></div><div align="center"><span style="font-size:85%;">Gets you on the run</span><span style="font-size:85%;"><br /><br />--Chorus--<br /><br /></span></div><div align="center"><span style="font-size:85%;"></span></div><div align="center"><span style="font-size:85%;">I've been running</span></div><div align="center"></div><div align="center"><span style="font-size:85%;">Ever since</span></div><div align="center"><span style="font-size:85%;">Ever since I was a child</span></div><div align="center"><span style="font-size:85%;">Some call it free</span></div><div align="center"><span style="font-size:85%;">And some call it wild</span><span style="font-size:85%;"><br /><br />There will be<br />There will be<br />There will be a light<br />There will be a light<br />There will be<br />There will be<br />There will be a light<br />There will be a light</span></div><br />Why is Lp(a) elevated for some individuals? Why is it directly correlated with premature vascular disease (when BP is elevated)?<br /><br />It's estimated there are potentially three families of factors that influence Lp(a) which affects about 17-25% of the general population:<br />(a) Structure and metabolism of very-low-density lipoprotein (VLDL) such as triglycerides, phospholipids, apoC-II, C-III, E, A-II and uric acid<em> <a href="http://drbganimalpharm.blogspot.com/search/label/Insulin">(which are of course ALL related to insulin)<br /></a></em>(b) Thrombosis-related centering on platelets<br />(c) Acute phase reactions represented by 1 hr and 2 hr erythrocyte sedimentation rates (ESR) <em>(in other words, immune system stimulation)</em><br />(I'd add a 4th factor in the formula (d) <em>kidney dysregulation</em> which is the site of Lp(a) catabolism and recycling/disposal in the human body)<br /><br /><a class="authors" href="http://www.ncbi.nlm.nih.gov/pubmed/9225216?ordinalpos=1&amp;itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum"><em><span style="font-size:85%;">Nakajima K, Hata Y.</span></em></a><em><span style="font-size:85%;"> Intraindividual variations in lipoprotein (a) levels and factors related to these changes. J Atheroscler Thromb. 1996;2(2):96-106. PMID: 9225216</span></em><br /><br /><br /><br />At TrackYourPlaque.com we have several reports addressing Lp(a). The challenge in controlling this one single, severe plaque-building factor can not be underestimated. It can be an unrelenting foe...<br /><br />-Lp(a) Report I (2006): <a href="http://trackyourplaque.com/library/fl_02-003lipoproteina.asp">Lipoprotein(a): What it is, why it's important, and why you need to know if you've got it!</a><br /><br />-Lp(a) Report II (2008): <a href="http://trackyourplaque.com/library/fl_01-019lpa_treatments.asp">Unique Strategies for Lipoprotein(a) Reduction</a><br /><br />-Lp(a) <a href="http://trackyourplaque.com/library/fl_01-009checklpa.asp">Lipoprotein Checklist</a><br /><br /><br /><br />There appear to be distinct subpopulations affected by Lp(a) from my (anecdotal, untrained) nonscientific observations:<br /><br />--high-carb consuming <a href="http://heartscanblog.blogspot.com/2007/07/mr-salazar-check-your-lpa.html">well known athletes</a> (and <a href="http://www.biblelife.org/exercise.htm">unknown</a>) who drop dead at endurance events of MIs (Brian Maxwell Northern Cal POWERBAR guru, Jim Fixx, and lucky survivor-Alberto Salazar)<br />--advanced stage chronic kidney disease (CKD)<br />--end-stage-renal-disease (ESRD) and dialysis patients<br />--individuals with <a href="http://www.ncbi.nlm.nih.gov/pubmed/9604816">kidney stones<br /></a>--individuals with Metabolic Syndrome (MetSyn) with premature heart disease in the family tree (females affected before age 65; males affected before age 55)<br />--men with <a href="http://www.ncbi.nlm.nih.gov/pubmed/16625232">diabetes Type 2 and erectile dysfunction</a><br />--individuals with MetSyn who have survived cancer (a condition that really sets off acute phase reactions and the immune system to heal)<br />--youth and young children with MetSyn, <a href="http://www.ncbi.nlm.nih.gov/pubmed/18307419">esp PCOS</a> or any other hormone derangements (ie, wheat addiction/prolactin, big-man-boobs, appear 4-mos pregnant and they are male )<br />--children with <a href="http://www.ncbi.nlm.nih.gov/pubmed/10780336">elevated insulin and apo B</a><br />--adults with <a href="http://www.ncbi.nlm.nih.gov/pubmed/18418227">elevated insulin and apo B</a> (and this is much more toxic for women for some reason than men)<br />--women <a href="http://atvb.ahajournals.org/cgi/content/full/16/10/1215">after menopause</a>, esp if no hormone replacement occurs<br /><br /><br />Can we avoid the dangers of running with scissors (or chopsticks)?<br /><br />I certainly believe so. (Heed the words of your mother)<br /><br />Let's keep running... wild and free... until we melt with the sun...<br /><br /><br />Lp(a): PPAR-Delta... Dagger in the Heart of Lp(a) (Part II) coming soon...Dr. B Ghttp://www.blogger.com/profile/15451872961651116061ramaramax@gmail.com