Alzheimer's and you.

Drugs Looks Promising for Alzheimer's disease

2009-07-07T12:02:00.000-07:00

More than 6 million Americans have Alzheimer's disease and well over 10 million baby boomers are expected to develop it in the coming years, which is why there's so much excitement about research being presented this week at a major conference of Alzheimer's experts.

New pill may restore memory loss in less than four weeks.
Dr. Marie Savard, boiled down some of the new developments that will be discussed at the conference.

Alzheimer's can be caused by the build-up of plaque in the brain and by fibrous tangles which wrap around nerve cells in the brain and kill the cells. Previous drugs have attacked the plaque, not very successfully.

A study was published recently that showed a drug called AL 108, which is actually a new type of nasal spray, attacks those fibrous tangles. Patients given AL 108 showed significant improvement in short-term memory after just four weeks and exhibited no side effects.

Testing of the drug is in early phase 2 trials, so a cure is not around the corner and there is no cure right now, but many researchers are excited about the findings.

Researchers at the conference will also present information about a powerful new test to detect Alzheimer's using PET scans.

PET scans have been very useful in detecting early-stage cancer, and researchers hope this new test could detect Alzheimer's as early as 10 years before people show symptoms of the disease, allowing them to begin treatment earlier.

The PET scan tests for Alzheimer's could be approved by the Food and Drug Administration in the next three or four years. PET scans are already widely used in hospitals to test for cancer and other diseases.

Antihistamine Looks Promising for Alzheimer's Patients
Alzheimer's disease can be heartbreaking to watch and frustrating to treat. Most medicines on the market do little more than delay the inevitable mental decline.

Preliminary tests show that Dimebon helps in restoring some memory.
But a new drug called Dimebon appears to stop and perhaps even reverse the symptoms of the cruel and degenerative disease, according to a new study published in the journal Lancet today.

"I was pleasantly surprised to see the effect on cognitive function, on memory, on activities of daily living that not only were clearly significant but seemed to increase over time," said Dr. Sam Gandy, former chairman of the Alzheimer's Association Medical and Scientific Advisory Council.

Dimebon wasn't designed to treat Alzheimer's disease. Far from it. It's an antihistamine that was supposed to treat allergies.

But a study that tracked 120 mild to moderate Alzheimer's patients for a year, and found that at six months those taking Dimebon three times a day showed significant improvement in mental tests and cognitive functioning, while those placed on the placebo kept deteriorating. A year into the study, the Dimebon group was still improving, while those without the drug were declining rapidly.

Hopes Dashed for Alzheimer's Drug
Researchers Abandon Flurizan; Doctors Hold Out Hope for Effective Approach
Many Alzheimer's researchers deny that the failure of a promising remedy for the degenerative disease requires a return to the drawing board, saying the setback is not a death knell for drugs designed to target a protein in the brain considered the trigger for the disease.

Still, doctors are disappointed that the treatment fell short of expectations -- especially when its makers spent $60 million on it during the past year alone.

On June 30, Myriad Genetics Inc. announced that its drug Flurizan didn't improve cognitive function or performance of daily activities for people who have Alzheimer's disease. A recent clinical trial tested the drug for 18 months in patients with a mild form of the condition.

"We are disappointed that Flurizan failed to achieve significance in this study, and we will now discontinue development of this compound," Myriad's CEO Peter Meldrum said in a statement.

Flurizan targeted one type of protein in the brain called beta amyloid. Researchers believe that the protein forms clumps that clog the connections between brain cells, which may contribute to the symptoms of Alzheimer's, which include progressive memory loss.

It was hoped that Flurizan would decrease the production of beta amyloid and slow the progression of the disease.

However, many scientists say they were not surprised by the findings. In fact, they say they even expected the outcome after seeing the underwhelming results of an earlier trial of the drug.

"The bottom line is that Flurizan was a nonstarter from the very beginning," says Rudy Tanzi, professor of neurology at Harvard Medical School in Boston. Tanzi is also the co-founder and shareholder of two companies that develop Alzheimer's treatments.

When results released in 2006 did not show an overall positive effect of Flurizan on brain function, Myriad researchers narrowed the patient population to target a small subgroup of people who benefited from the drug. They used this population -- patients who had mild Alzheimer's disease and took a high dose of the drug -- in the most recent trial.

But by that time, the earlier trial had already "cast considerable doubt on the potency of the drug in Alzheimer's disease," says Dr. Sid Gilman, director of the Michigan Alzheimer's Disease Research Center in Ann Arbor, Michigan...

"I have been skeptical of this all along," Gilman added.

Where to Go From Here
Doctors say that this latest defeat in the fight against Alzheimer's gives no indication of the state of research relating to the disease.

"Flurizan was the first shot on goal, but it was a shot from the 50-yard-line by a fifth grader," Tanzi says. "This is by no means a failure of all drugs that target amyloid beta."

Dr. Ronald Petersen, director of the Alzheimer's Disease Treatment Center at the Mayo Clinic in Rochester, Minn., agrees and says, "There are many other alternatives in the pipeline that show promise."

Among these are drugs aimed at various targets, Gilman says, including the immune system, receptors for various chemicals that bathe brain cells, and other pathways for stopping the pesky proteins that researchers believe contribute to Alzheimer's symptoms.

But treating and curing the condition may require a tag team of therapies to achieve the most effective results.

"I suspect that the reality is that attacking the amyloid cascade is a complicated issue, and no single therapeutic strategy is likely to be the final answer," Petersen says.

Scientists are optimistic that even with Flurizan's demise, a plausible treatment will emerge soon.

"History has shown that when you have a new mechanism and a new target, inevitably the first wave of drugs is usually the worst," Tanzi says, referring to the findings from Flurizan. "In these situations you need to be patient and wait for the second or third wave of drugs. ... That wave is coming."

There are still no CURE of any kind for Alzheimer's disease today on the world market... Dr.William Thomas.

Mary Joseph Foundation a non-profit organization for Alzheimer's disease.
137 1/2 Washington Ave, Suite 292
Belleville, NJ 07109
201-336-0075

How and why we raise funds.

2009-07-07T11:56:00.000-07:00

The services Mary Joseph Foundation provides to raise funds for individuals who have Alzheimer's disease and young hungry children here and around the world.

( 1 ) We do Consulting and Lecturing on Security, Security, Network and Design Engineering, international Law and Constitutions to Governments and Businesses around the world.

( 2 ) We give talks on Security, Energy, Medicines, Religion, Engineering, Politics and international public relations.

( 3 ) We develop and sell our products for memory and Brain, to help individuals avoid getting Dementia/Alzheimer's.

To all Governments, Businesses and Universities here in America and around the world, I hope that we at the Mary Joseph Foundation a non-profit organization will get the chance to provide our services to your institutions, now and in the future.

All of our speakers and lecturers are expert in their fields, they are political and fortune 500 corporations leaders from around the world.

Over 90 percent of all funds raise from speaking, consulting and lecturing goes to helping individuals who have Alzheimer's disease and young children who are hungry here and many third world countries. We provides rooming, foods, vitamins, medicines and caring for individuals with Alzheimer's disease especially those who are living in homes for the insane and crazy, on the street and homeless, we also provide foods for young hungry children especially in the third world countries. Mary Joseph Foundation provides all these services for FREE.

Please support us in our non-profit work, there is always a greater happiness in giving than in receiving. We are always looking for partners to work with especially in the third world countries.

www.maryjosephfoundation.org

www.maryjosephfoundation.blogspot.com

www.marycharityfoundation.blogspot.com

Fred Joseph

President

Former senior security engineer Citi Bank, JP MorganChase, IBM and the Federal Government.

137 1/2 Washington Ave, Suite 292, Belleville, New Jersey 07109

The loving letter to all Americans that make me cry.

2009-07-07T11:48:00.000-07:00

Letter from President Ronald Reagan to the American people:
Nov. 5, 1994

My Fellow Americans,

I have recently been told that I am one of the millions of Americans who will be afflicted with Alzheimer’s disease.

Upon learning this news, Nancy and I had to decide whether as private citizens we would keep this a private matter or whether we would make this news known in a public way.

In the past, Nancy suffered from breast cancer and I had my cancer surgeries. We found through our open disclosures we were able to raise public awareness. We were happy that as a result, many more people underwent testing.

They were treated in early stages and able to return to normal, healthy lives. So, now we feel it is important to share it with you. In opening our hearts, we hope this might promote greater awareness of this condition. Perhaps it will encourage a clearer understanding of the individuals and families who are affected by it.

At the moment I feel just fine. I intend to live the remainder of the years God gives me on this earth doing the things I have always done. I will continue to share life’s journey with my beloved Nancy and my family. I plan to enjoy the great outdoors and stay in touch with my friends and supporters.

Unfortunately, as Alzheimer’s disease progresses, the family often bears a heavy burden. I only wish there was some way I could spare Nancy from this painful experience. When the time comes I am confident that with your help she will face it with faith and courage.

In closing, let me thank you, the American people, for giving me the great honour of allowing me to serve as your President. When the Lord calls me home, whenever that may be, I will leave with the greatest love for this country of ours and eternal optimism for its future.

I now begin the journey that will lead me into the sunset of my life. I know that for America there will always be a bright dawn ahead.

Thank you, my friends. May God always bless you.

Sincerely,

Ronald Reagan

I will always LOVE you.

http://www.maryjosephfoundation.blogspot.com
http://www.miltilinkwithpeoplesandcorpor...gspot.com/

Mary Joseph Foundation a non-profit organization for Alzheimer's

Alois Alzheimer

2009-07-07T11:47:00.001-07:00

Alois Alzheimer was born in 1864 in Markbreit in Bavaria, Southern Germany. Excelling in sciences at school he studied medicine in Berlin, Aschaffenburg Tubingen and Wurzburg where he graduated with a medical degree in 1887. He began work in the state asylum in Frankfurt am Main, becoming interested in research on the cortex of the human brain. Here he commenced his education in psychiatry and neuropathology.

Along with Franz Nissl, a colleague at the asylum, Alzheimer spent the following years working on a major six volume study, the 'Histologic and Histopathologic Studies of the Cerebral Cortex,' describing the pathology of the nervous system. The work was finally published between 1907 and 1918. In 1895 Alzheimer was appointed director of the asylum where he continued his research on a number of subjects including manic depression and schizophrenia.

Today, the pathological diagnosis of Alzheimer's disease is still generally based on the same investigative methods used in 1906. This is remarkable compared with the development of investigative methods for other diseases, and it speaks volumes about the quality of Alzheimer's discovery.

Alzheimer's disease is the most common cause of dementia and accounts for 65% - 80% of all cases. It destroys brain cells and nerves disrupting the transmitters which carry messages in the brain, particularly those responsible for storing memories. Alzheimer's disease was first described by A. Alzheimer's in 1906.

During the course of Alzheimer's disease, nerve cells die in particular regions of the brain. The brain shrinks as gaps develop in the temporal lobe and hippocampus, which are responsible for storing and retrieving new information. This in turn affects people's ability to remember, speak, think and make decisions. The production of certain chemicals in the brain, such as acetylcholine is also affected. It is not known what causes nerve cells to die but there are characteristic appearances of the brain after death. In particular, 'tangles' and 'plaques' made from protein fragments are observed under the microscope in damaged areas of brain. This confirms the diagnosis of Alzheimer's disease.

Currently there are over 18 million peoples worldwide who are living with Alzheimer’s disease and that number is expected to grow to as many as 71 million by 2025. Alzheimer’s disease is the seventh leading cause of death in the United States and number six worldwide.

Mary Joseph Foundation for Alzheimer's disease

http://www.miltilinkwithpeoplesandcorporations.blogspot.com/

New Report Says over 10 Million Americans Will Develop Alzheimer's disease in the near future

2009-07-07T11:40:00.000-07:00

Every 22 seconds in the world and every 71 seconds in this country, someone is diagnosed with Alzheimer's disease, and a startling new report out today from the Alzheimer's Association predicts that one out of every eight baby boomers — or almost 10 million Americans — is expected to develop the disease sometime in the near future. If new treatments are years away, is there anything you can do today that might prevent it?

Fran Hershkowitz's mother began losing her memory more than a decade ago, and now Fran, who is 63, worries if he might be next.

"It's frightening, too, to think that one day this is going to be me." the younger Hershkowitz said. Evidence shows that physical exercise may be the most effective remedy today to prevent Alzheimer's disease, and large health studies have shown that people who stay physically active are less likely to develop the disease. Scientists put that idea to the test. Researchers bred mice to develop the specific kind of plaque in the brain, as seen in Alzheimer's disease. Some mice were allowed to exercise, and some were not. The autopsy results were stunning.

The brains of sedentary mice were riddled with the harmful plaques, but the physically active mice had 50 to 80 percent less plaque. Further tests revealed that the mice who exercised produced twice as much of an enzyme in the brain that prevents plaque buildup. The exercise also produced twice as many tiny blood vessels in the brain to allow plaques to escape. "Moving plaques from the brain into the blood, so it's carried to those organs like the liver where it can be destroyed," said Professor Sangram S. Sisodia, a neuroscientist at the University of Chicago and lead investigator in the study. Population studies suggest any exercise that raises your heart rate for 30 to 45 minutes at least several times a week can lower your risk of Alzheimer's. And the more the exercise you get, the lower your risk. "Regular physical exercise is probably the best means we have of preventing Alzheimer's disease today," said Dr. Ronald Petersen, director of the Alzheimer's Research Center at the Mayo Clinic in Rochester, Minn.

"There are other possible intervention, including diet, and supplements, intellectual activities, but the data indicate that physical activity is the most likely to prevent this disease," Doctor William Thomas said. For family members determined to avoid another generation of this disease, there is finally preventative action they can take, which they won't have to wait for.

"Regular physical exercise is probably the best means we have of preventing Alzheimer's disease today." Dr. Ronald Petersen of the Mayo Clinic Alzheimer's Disease Research Center said. "Better than medications, better than intellectual activity, better than supplements and diet."

For family members determined to avoid another generation of this disease, there is finally preventative action they can take, which they won't have to wait for.

www.maryjosephfoundation.org

Mary Joseph Foundation a non-profit organization for Alzheimer's disease.
137 1/2 Washington Ave, Suite 292, Belleville, NJ 07109.

http://www.miltilinkwithpeoplesandcorporations.blogspot.com/

http://www.marycharityfoundation.blogspot.com/

A world without Alzheimer's and hungry Children.

2008-12-10T09:12:00.000-08:00

We really cares about you!

Our main gold is to eliminate Alzheimer's disease through the advancement of research; at the same time to provide and enhance care and support for all affected by this disease; and to reduce the risk of dementia through the promotion of brain health. We are working very hard so that one day there would be a world without Alzheimer's disease, but for now with your donations its allow us to build homes, give medicines, foods, vitamins, caring and remove individuals who have Alzheimer's disease from the street who are homeless and from mental homes and cares for them, our services are FREE.

It hurt me very, very much that tears some times come to my eyes to see so much people here in America and around the world suffering from Alzheimer's disease and the children who go with out foods and many times are homeless.

Mary Joseph Foundation cares and we are doing everything possible to eliminate Alzheimer's disease, homelessness and hunger.

We are looking for more companies to work with us on Alzheimer's disease and children who are hungry and homeless.

To help please send all mails and donations to: Mary Joseph Foundation a non-profit organization, 137 1/2 Washington Ave, Suite 292, Belleville, NJ 07109
website www.maryjosephfoundation.org

Melrose Joseph
Director

Special project 81-49222-005A 2009

2008-11-18T09:17:00.000-08:00

We have come along way and I want to personally thank each and everyone of you for your support and tell you how important it is.With early onset of Alzheimer's detection and treatment the chance of slowing it down is much greater.As a special program of the Alzheimer's Foundation for detection of symptoms and prevention the mission of the Alzheimer's assistance relief fund is to support educational, prevention, medical assistance and relief, and innovative research programs in order to reduce the incidence of early onset of Alzheimer's disease in America and throughout the rest of the world.The Alzheimer's assistance relief fund is also fully committed to directly assisting patients, and caregivers with the personal devastation caused by Alzheimer's disease.

There are still no CURE of any kind for Alzheimer's disease today on the world market... Dr.William Thomas.

Thank you for your generous support, your gifts of $1.00 --$2.00 --$5.00 and $10.00, it provides and continue to provide another step closer to finding a CURE for Alzheimer's and at the same time helping those who have Alzheimer's disease, chance for life.

For every ten dollars $25 donation or more you make to the Alzheimer's assistance relief fund, you will get a gift from us that value upward of $20.000 in saving on food...We just want to say thank for your support.

Just by sending $1.00 or $2.00 it would be very, very much appreciated.With my humble and deepest gratitude,

Melrose Joseph,
Director for special needs

Please make check or money order payable to:
Mary Joseph Foundation for Alzheimer's disease
137 1/2 Washington Ave, Suite 292
Belleville, NJ 07109.
201-336-0075
http://www.miltilinkwithpeoplesandcorpor...gspot.com/
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Sandra Day O'Connor makes plea for Alzheimer's FUNDING!

2008-11-02T05:22:00.000-08:00

WASHINGTON... Speaking out for the first time about her husband's Alzheimer's disease, retired Justice Sandra Day O'Connor told senators Wednesday that the disease takes a "staggering toll" on families and said, "our nation is certainly ready, and have to get deadly serious about this deadly disease."
As she referred to her "beloved husband," John, and how he is "not in very good shape," her voice cracked.

Who feel it knows it...Living with this disease has been sad and difficult for my entire family or any family," O'Connor wrote in the testimony she prepared for Wednesday's morning session. "The disease begins quietly, with memory difficulties that gradually become more serious and much more frightening with each passing year. Then, what follows is confusion ... impaired judgment ... trouble expressing even the simplest thoughts .... disorientation ... and socially inappropriate behavior." Yet Sandra Day O'Connor who was the first woman on the Supreme Court, clearly conveyed her main message to the Special Committee on Aging: that Alzheimer's disease research must be expanded to find a CURE, and it will take both public and private funding, I must say every dollar count.

Speaking from experiences In Sandra Day O'Connor's actual remarks to the committee, she did not read that text and instead highlighted the need for policymakers to focus on research of this deadly disease that currently has no cure.

Recently, researchers identified abnormal tau protein in the entorhinal cortex before dementia was even clinically detectable. For years now most researchers targeted a different symptom, the amyloid beta plaques that gum up the spaces between the brain's neurons, causing them to die. You can now see many famous people such as Charlton Heston 1924-2008,former President Ronald Reagan and more who die from Alzheimer's disease on our web site ( my forum )

We are asking everyone for their support let us fight this disease together, I watch my mother and two of my cousins slowly past away from Alzheimer's disease.

F Joseph
Mary Joseph Foundation
137 1/2 Washington Ave.Suite 292
Belleville, New Jersey 07109

We are trying our best to find a cure and at the same time helping individuals who have Alzheimer's disease.
There are still no CURE of any kind for Alzheimer's disease today on the world market... Dr.William Thomas.

Mary Joseph Foundation a non-profit organization for Alzheimer's disease.

Every 22 seconds in the world and 71 seconds in America someone get Alzheimer's

2008-11-02T05:19:00.000-08:00

Autobiographical memory: Memory for the personal events and facts of one's life.

There is no single concept called " memory " There are two overarching types: short-term, which allows you to remember the beginning of this sentence by the time you reach the end of it, and long-term, which includes unconscious habits and reflexes, general facts and knowledge, and autobiographical memory ... memory for the personal details, facts and experiences of your life.

Just like the rest of our bodies, our brains change as we age. Most of us notice some slowed thinking and occasional problems remembering certain things. However, serious memory loss, confusion and other major changes in the way our minds work are not a normal part of aging.

Is a progressive and fatal brain disease. There are over 6 million Americans now have Alzheimer’s disease. Alzheimer's destroys brain cells, causing problems with memory, thinking and behavior severe enough to affect work, lifelong hobbies or social life. Alzheimer’s gets worse over time, and it is fatal. Today it is the seventh-leading cause of death in the United States.

We are doing everything possible to help individuals who have Alzheimer's disease and also to find a cure.

Changing The Present helps nonprofit's raise awareness Alzheimer's disease and raise money by making charitable giving more convenient, cost-efficient, and rewarding than ever before.

Register for a Premium membership for just a donation per year to take full advantage of our FREE services and online purchasing and fundraising.

Remember someone develops Alzheimer's disease
every 22 seconds and it could be you.

Don't let Alzheimer's steal
you or your love one dreams. Act now !!!

Mary Joseph Foundation a non-profit organization for Alzheimer's disease
137 1/2 Washington Ave, Suite 292
Belleville, NJ 07109
201-336-0075
www.maryjosephfoundation.org

To really see the suffering and pain that Alzheimer's disease causes you have to really see and experience the suffering of your dear love one, it was very, very hard for me to see my mother in so much pain, that many times tears would start coming from my eyes.

http://www.maryjosephfoundation.blogspot.com
http://www.marycharityfoundation.blogspot.com

All funds are going to help individuals who have Alzheimer's and hungry children.

2008-03-10T13:53:00.000-07:00

Alzheimer's disease and the affects.

2008-03-02T14:02:00.000-08:00

A few days ago several studies on Alzheimer's disease show

memories are first processed in the entorhinal cortex, which also is where Alzheimer's seems to begin its spread.

Evidence at the cellular level shows there are two causes for the onset of Alzheimer's. Starchy plaques crowd the space between brain cells. Tangles of tau proteins clomp together, sabotaging communication pathways.

For such important structure, little is known about the circuitry of the entorhinal cortex. What is known is that the activity levels of its neurons seem to predict whether something will be remembered or forgotten, for example the entorhinal cortex is the first area in the brain damaged by Alzheimer's. It is like a small fire set by an arsonist, the disease smolders here, then works upward through the centers of speech and language and spreads across the ceiling of the brain, moving into the visual cortex in the back, the motor cortex in the front, then into the most forward part, where cognition, judgment and reasoning reside.

Having dismantled the walls and floors of the brain's major lobes, Alzheimer's descends into the subcortex , finally attacking the brain stem and choking off the most basic processes of life, swallowing, breathing, blood pressure.

Recently, researchers identified abnormal tau protein in the entorhinal cortex before dementia was even clinically detectable. For years now most researchers targeted a different symptom, the amyloid beta plaques that gum up the spaces between the brain's neurons, causing them to die.

We are our memories, and almost everything we do is guided by the experiences we have had. All of our skills, our aspirations, our hopes, dreams, and imagination come out of our experiences and the accumulated benefit we have derived from them.

It is that very foundation, however, that turns tremulous for those with Alzheimer's.

All such memories are an amalgam of associations.

We are trying our best to find a cure and at the same time helping individuals who have Alzheimer's.

There are still no Cure on the market today for Alzheimer's disease...Dr. William Thomas.

http://www.miltilinkwithpeoplesandcorpor...ogspot.com
www.maryjosephfoundation.org
Mary 1-2008

More about Alzheimer's disease

2008-02-17T15:00:00.000-08:00

Until the late 1970s, the study of such personal memory was not considered suitable for scientific inquiry. Whatever played across the mind's screen was private and unknowable to the outside world.This lack of knowledge about how memory works made it almost impossible to unravel one of medicine's most vexing questions - the cause of Alzheimer's, an age-related disease affecting more than six million Americans.

But an examination of the latest research, some of it not yet published, shows that, neuron by neuron, scientists are finally making their way into the deepest recesses of human memory. Like the first blurry, black-and-white pictures sent back from the surface of the moon, the view is still imperfect, but memory's secret landscape is slowly being revealed.For example Scientific are now using laser and different type of wire devices to cause regression to the memory.

Science is unlocking many of the mysteries of the brain, but we don’t have all the answers yet. You can do everything “right” and still not prevent Alzheimer’s disease. What’s offered here is the best and most up-to-date information available so that you can make your own decisions about your health.

Mary Joseph Foundation

http://www.miltilinkwithpeoplesandcorpor...ogspot.com

http://www.maryjosephfoundation.blogspot.com

http://www.marycharityfoundation.blogspot.com

Anyone can get this deadly disease.

2007-10-15T06:44:00.000-07:00

Letter from President Ronald Reagan to the American people:
Nov. 5, 1994

My Fellow Americans,

I have recently been told that I am one of the millions of Americans who will be afflicted with Alzheimer’s disease.

Upon learning this news, Nancy and I had to decide whether as private citizens we would keep this a private matter or whether we would make this news known in a public way.

In the past, Nancy suffered from breast cancer and I had my cancer surgeries. We found through our open disclosures we were able to raise public awareness. We were happy that as a result, many more people underwent testing.

They were treated in early stages and able to return to normal, healthy lives. So, now we feel it is important to share it with you. In opening our hearts, we hope this might promote greater awareness of this condition. Perhaps it will encourage a clearer understanding of the individuals and families who are affected by it.

At the moment I feel just fine. I intend to live the remainder of the years God gives me on this earth doing the things I have always done. I will continue to share life’s journey with my beloved Nancy and my family. I plan to enjoy the great outdoors and stay in touch with my friends and supporters.

Unfortunately, as Alzheimer’s disease progresses, the family often bears a heavy burden. I only wish there was some way I could spare Nancy from this painful experience. When the time comes I am confident that with your help she will face it with faith and courage.

In closing, let me thank you, the American people, for giving me the great honour of allowing me to serve as your President. When the Lord calls me home, whenever that may be, I will leave with the greatest love for this country of ours and eternal optimism for its future.

I now begin the journey that will lead me into the sunset of my life. I know that for America there will always be a bright dawn ahead.

Thank you, my friends. May God always bless you.

Sincerely,

Ronald Reagan

Please support us in our non-profits work here and in many third world countries, especially in the third world countries it is real bad.

alzheimers@maryjosephfoundation.org

www.maryjosephfoundation.org

The deadly disease that affect us in so many ways.

2007-10-02T11:42:00.000-07:00

Alzheimer’s: the long and slow goodbye.

In honor of the late Mary Joseph who past from Alzheimer's disease in 1998.

Alzheimer’s disease was first diagnosed just over 100 years ago, yet it remains an area of high unmet medical need with a heavy burden of care. So where is research taking companies?

Whoever and wherever the patient, Alzheimer’s disease can leave a trail of worn out, broken-hearted relatives as they care for their loved one on a journey that cannot be reversed.

Alzheimer’s is a progressive, irreversible brain disorder with a poorly understood cause and no known cure. It attacks and slowly steals the minds of its victim and brings heartache to the career, often a relative, who must watch their loved one slip away to a loathsome thief.

Symptoms of Alzheimer’s include memory loss, confusion, impaired judgment, personality changes, disorientation and loss of language skills. It is the most common form of irreversible dementia.

In the absence of better therapy, this global health problem will only get worse as populations age. It is estimated there will be over 51 million patients with dementia by 2020.

Understanding the needs of people with Alzheimer’s

Myths and misconceptions about Alzheimer’s

The World Health Organization says Alzheimer’s disease has many myths and misconceptions.

For example, some people regard the disease as the same as ‘going mad’, and others ask about the need to go to a doctor if Alzheimer’s is ‘part of getting old’.

As a director in the Business and Commercial Analysis group of GSK's Research & Development division, one of Jaron Ballentine’s responsibilities is to help the company better understand the needs of patients and physicians so it can develop better medicines.

In the case of Alzheimer’s, however, there is an additional need. “Alzheimer’s is a condition that affects not only the patient but also the career, the patient’s family and society as a whole,” he says.

While the core symptoms are memory and cognition loss, these can lead to other symptoms and physical ailments. "If an Alzheimer’s patient has trouble remembering the names of close friends and answering questions in social situations, chances are that this will eventually result in embarrassing social situations. In turn, this will lead to a lack of confidence and withdrawal," says Jason.

Caring for the care-giver

Alzheimer’s concerns more than the patient, of course. Most have a career or care-giver who takes primary responsibility for their well-being. This person is usually a loved one – over 80 per cent of careers are a partner, spouse or relative, usually a son or daughter. A majority of careers are retired or homemakers; about 30 to 40 per cent have part-time or full-time jobs which place additional burdens on them. The time given to caring has been compared to having another job.

“Regardless of the circumstance, caring for an Alzheimer’s patient takes dedication and self-sacrifice. We are told that 70 per cent of care-givers have
reported they have decreased social activities as a result of being a care-giver. About half of them have limited hobbies or have given them up, and almost ten per cent have changed or given up their job.” This significant care-giver burden is a factor that is now measured in Alzheimer’s trials at GSK. “The hope is that the medicines we are developing for Alzheimer’s will not only benefit the patient but also improve the care-giver’s quality of life.”

Alzheimer’s is a condition that affects not only the patient but also the career, the patient’s family and society as a whole.

The emotional aspects of Alzheimer’s should not be forgotten. “Most careers are either a husband or wife, or a son or daughter, and they love the patient dearly. They recognize that while it is a significant sacrifice, they feel strongly that they want to take good care of their loved one and ensure they are well cared for and comfortable. It is the family who sees the patient slowly fade away, in what many call ‘the long goodbye’.”

Research directions for Alzheimer’s
So what are companies such as GSK doing to combat this soul-destroying disease?

Current mainstream therapies work by reducing the degradation of the neurotransmitter acetylcholine in the synapse (the region where nerve impulses are transmitted and received between nerve cells). If the level of acetylcholine in the synaptic areas of the brain can be maintained, memory dysfunction can be improved.

”Some of the therapies we are developing modulate and up-regulate the release of neurotransmitters. Other approaches endeavour to mimic the effect of the missing neurotransmitters or increase the response of the receiving cells to those transmitters,” says John Davis, director of one of the Molecular Discovery Research units in GSK's Research & Development division.

Avenue of exploration
The fact that energy metabolism appears to be affected in Alzheimer’s disease is offering GSK a further avenue of exploration. “Drugs that can modulate glucose utilization, like those currently used in diabetes, are a good bet in trying to modulate glucose utilization in the brain,” says John.

“By having a number of symptomatic approaches, we hope to produce new therapies for patients that have improved or different side-effect profiles. We also hope to produce improved efficacy - or at least efficacy that can be added to existing treatments - so that the armoury which physicians have to combat the disease is increased.”

However, the problem with symptomatic treatments is that they do not tackle the underlying progression of the disease. “If a patient’s drug is removed, we may find that their condition deteriorates rapidly in response, so we are also looking for disease-modifying therapies that will tackle the underlying cause of the disease.”

Going back to Alois Alzheimer

As well as having a number of symptomatic treatments in the clinical pipeline, GSK is looking at somehow modifying the disease.

Alzheimer’s facts

About 18 million people worldwide are estimated to have Alzheimer’s
More than 50 per cent of people with Alzheimer’s live in developing countries. By 2025, this will be over 70 per cent
Alzheimer’s can occur at any age, even as young as 30 years
The total worldwide cost of dementia care is estimated to be US $360.4 billion annually.
It is currently not possible to predict who will get Alzheimer’s - it can strike anyone irrespective of gender, caste, creed, culture or socioeconomic status
21 September marks Alzheimer’s Disease Day, organised by the Alzheimer’s Disease International, an umbrella body for Alzheimer’s groups around the world.

Here, researchers have returned to some of Alois Alzheimer’s original observations, one of which concerns characteristic plaques in the brain. These contain a substance called beta-amyloid, which is thought to be important in the progression of the disease.

GSK is investigating a number of disease modifying approaches that aim to lower amyloid levels in the brain.

Focus on the Alzheimer’s patient
"In the past few years we have been conducting some ground-breaking work using large patient populations to work out how patients can help in developing new therapies and approaches towards delivering drugs," says John.

"On the one hand we have conducted genetic association studies, where we can identify genetic mutations carried in the population that predispose those patients towards contracting or developing Alzheimer’s disease. The other way of using these large banks of data derived from patients is to look for biomarkers of the disease or physiological processes that can be targeted in the pathology of the disease." The hope is that these markers may then be used to manage the development of therapeutics more efficiently.

There are many people, among them the careers and those who are and will be patients, who are hoping the research paths being taken now - 100 years since Alois Alzheimer first described this saddening disease - are fruitful ones.

Build and protect your memory.

2007-09-23T13:18:00.000-07:00

Memory Companion;

It is a fortify blend formula with all natural herbal plants and all the essentials elements for everyone memory. Memory Companion maintain and keep your memory functioning properly and in great healthy condition, the memory is very important it is the faculty by which the mind stores and remembers information, more than ever in today world your memory need help and Memory Companion is the one you should be taking.

Memory Companion help produce new cells for growth and other vital functions that helps improve your memory by preventing and removing plaques from building up, it promotes mental function and healthy cells.

Memory Companion formula has in over twenty difference type of herbal plants, these plants are the most concentrated source of omega-3, amino acids, antioxidants and more vital essentials for your memory and Brain from all these natural herbal plants.

To avoid damage cells and plaque build up that causes Dementia/Alzheimer's, you need Memory Companion.

To buy Memory Companion please send $35.00 for a 22 oz bottle plus $4.00 for shipping and handling to,

Mary Joseph Foundation

137 1/2 Washington Ave

Suite 292

Belleville, New Jersey 07109.

alzheimers@maryjosephfoundation.org

www.maryjosephfoundation.org

Memory Companion only cost $35.00 per 22 oz bottle plus $4.00 for shipping and handling, remember every 22 seconds someone in the world will get Alzheimer's disease, so please protect yourself.

We guarantee your satisfaction when you use this product. If you are not satisfied, just return the unused portions for a full purchase price refund within 90 days of purchase.

What is Alzheimer's.

2007-09-21T13:33:00.001-07:00

About Alzheimer'S disease;

Alzheimer's disease is a degenerative disease characterized by progressive deterioration with declining activities of daily living and symptoms or behavioral changes, it is the most common type of Dementia. Alzheimer's is a progressive BRAIN disorder that cause by PLAQUES and gradually destroying the individuals memory and ability to learn and reason, make judgments, properly communicate with others and carry out daily activities. As Alzheimer's progresses, individuals will also experience changes in their personality and behavior, such as anxiety, suspiciousness or agitation and delusions back and forth from adult to a child like state and finally remain in a child like state.

Dr. William Thomas

www.maryjosephfoundation.org

Job postings.

2007-09-18T10:30:00.001-07:00

We have two opening;

Director, for future planning here in America and abroad, meeting with government and Business leaders.

Communications and Fundraising Specialist, setting up auctions, meeting with business leaders.

Send resume to alzheimers@maryjosephfoundation.org

Mary Joseph Foundation

137 1/2 Washington Ave, Suite 292

Belleville, New Jersey, 07109

Atten: Melrose Joseph

www.maryjosephfoundation.org

Caring.

2007-09-10T09:35:00.000-07:00

Yvonne,

There is a big problem today especially in many of these homes that are caring for your love ones with Alzheimer's,I see it first hand over and over, my mother was in the same condition so we had to take care of her ourselves, then traveling to many countries I saw many individuals who have Alzheimer's/Dementia living on the street homeless and some are put in homes for the insane, crazy and beaten sometimes by the guards. We at MARY JOSEPH FOUNDATION remove individuals who have Alzheimer's/Dementia from the street and homes for the insane, crazy and others bad places especially in the third world counties and take care of them like our own family. Yvonne it is ashame that these things happen to our love ones because we just want the best for our love ones, but in the mean time try talking to the head of the facility about feeding times and turning times for you love one.

Remember no one should ever go through this alone Alzheimer's disease, Alzheimer's disease bring you right down to nothing, it destroy you.

Thank you Yvonne for your email

Joan White, Director of care.

Mary Joseph Foundation feed, give vitamins, medicines, caring and rooming to individuals who have Alzheimer's/Dementia.
We continue to build homes and help individuals who have Alzheimer's disease.

We need volunteers.

2007-09-03T12:41:00.000-07:00

We are looking for volunteers in difference fields:

Management. Government. Building. Public relations. Patients care and others.

Today the world that we are living in, is such a small place and there are so, so much peoples who are suffering from so many difference types of disasters and diseases, here and around the world and these peoples need our help.

We at Mary Joseph Foundation cares for individuals who have Dementia/Alzheimer's disease by providing FREE foods, vitamins, medicines, caring and rooming for them.

We remove many Dementia/Alzheimer's individuals from the street and homes for the insane.

We at Mary Joseph Foundation hope to continue doing our best for individuals with Dementia/Alzheimer's here and in the third world countries.

Please send us an email alzheimers@maryjosephfoundaton.org with your work experience.

Dementia/Alzheimer's.

2007-09-01T12:14:00.001-07:00

Brain changes precede memory loss:

In some cases the disease is very difficult to detect until it has progressed from mild memory loss to clear impairment, individuals eventually loss all ability to care for themselves.

The Brain structure changes can be seen in clinically normal individuals an average of two years before they are diagnosed with mild cognitive impairment.

In Dementia/Alzheimer's disease cases, lesions known as ( plaques and tangles ) form in the brain, due to the abnormal clumping of two proteins called beta-amyloid and tau.

MRI showed loss of gray matter two to three years before symptoms.

In normal older individuals, MRI of the brain reveals loss of gray matter about two to three years before symptoms of the mind cognitive impairment set in.

Dr. William Thomas

Protect your memory and avoid Dementia.

2007-08-28T17:02:00.000-07:00

Build a strong memory:

Memory Companion is fortify with over twenty difference types of all natural herbal plants, in 2003 we tested Memory Companion on over one thousand individuals who had plaque problem with their memory and after six months of taking Memory Companion the plaque build up was removed and new cells reappear in the individuals brain.

We also realize when an individual take Memory Companion at a real early stage in life their memory tend to be plaque FREE.

Plaque is a sticky build up that form and deposit on certain parts of the brain which causes individuals to become forgetful and later Dementia/Alzheimer's.

Dr. William Thomas

www.maryjosephfoundation.org

Protect your Memory.

2007-08-22T10:44:00.000-07:00

George thank for your question?

Yes there are very good formulas out there to avoid Dementia, one of the best I know of and use myself is Memory Companion, and also use by thousands of peoples to help repair damage cells from dying off by removing the plaques and stop plaques from sticking to the cells and at the same time help boost your memory and protect it.

Joan thank for your question?

The memory is the faculty by which the mind stores and remembers information, and also the length of time over which people's memory extends, as we grow older we need to take care of our memory we think Memory Companion is one of the best product for the memory.

for more information on Memory Companion please send us an Email:

alzheimers@maryjosephfoundation.org

A few questions and answers.

2007-08-21T13:20:00.000-07:00

Thank Marjorie for your question?

Individuals who have Dementia goes through these changes because it is
A mental disorder marked by memory failures, personality changes, and
impaired reasoning.

Never argue back with him instead always invite him to do something else
and while he is doing something else you remove his pack baggage and
because of memory failure, when he return he will forget that he was
leaving.

Thank Shirley for your question?

You should always turn your mother every two hours in Bed to avoid damage
to her skin.

Please help us to help those in need.

2007-08-21T12:54:00.000-07:00

www.marycharityfoundation.blogspot.com

Please join us in helping to find a cure and continue feeding, giving medicines, vitamins and rooming to individuals who have Alzheimer's/Dementia. We provide these services for FREE because of your donations.

Mary Joseph Foundation
Suite 292
137 1/2 Washington Ave
Belleville, NJ 07109

alzheimers@maryjosephfoundation.org

Signs and symptoms of Alzheimer's.

2007-08-19T15:41:00.000-07:00

Question ask by most peoples?

How can we tell if memory loss is caused by Alzheimer's disease?
Are there any symptoms I should watch for and report?
What should I expect if it is Alzheimer's disease?
When should I come back for another visit?
Where can I go for more information?
If the memory loss is caused by Alzheimer's disease, which treatment is most appropriate?

Here are some of the symptoms:

Short-term memory loss, like repeating the same question several times.
Trouble remembering easy words, like saying "that thing I write with" instead of "pen or pencil ."
Not wanting to do things you usually enjoy doing such as cooking.
Making bad judgments, like turning the heat up too high, leaving the stove, walking out into the pouring rain without an umbrella, forgetting where you put your keys, to eat, or giving lots of money to a stranger for no reason, getting lost.
Extreme personality changes, mood swings and getting upset easily.
Confusing things and people from the past with things and people from the present.

there is no cure for Alzheimer's:

You can keep yourself healthy by taking vitamins, omega-3 fatty acids and others, to learn more email us at alzheimers@maryjosephfoundation.org

There are some medications can help slow Alzheimer's down, but first check with your Doctor.

Mary Joseph Foundation

Suite 292

137 1/2 Washington Ave

Belleville, NJ 07109

Looking at Dementia/Alzheimer's:

Dementia!

A mental disorder marked by memory failures, personality changes, and impaired reasoning.

Alzheimer's!

A form of progressive mental deterioration occurring in middle or old age and in some rare cases individuals in their thirties.

These causes individuals to become forgetful and confused and slowly robbing them of their memory, it happen when the brain cells die and a sticky plaques form and cover over certain parts of the brain.

Do you have a question send us an email: alzheimers@maryjosephfoundation.org