Anti-Aging Research

N-Acetyl Cysteine May Help Treat Patients With Compulsive Behavior

2009-07-10T20:58:00.000-07:00

The amino acid N-acetyl cysteine appears to reduce symptoms of compulsive hair-pulling in patients with a condition known as trichotillomania, according to a report in the July issue of Archives of General Psychiatry, one of the JAMA/Archives journals.

Psychosocial problems are common in individuals with trichotillomania and include significantly reduced quality of life, reduced work productivity and impaired social functioning. N-Acetyl Cysteine's efficacy lends further support to the hypothesis that therapies manipulating the glutamate system (called glutamatergic agents) may target core symptoms of compulsive behaviors.

View details on this N-Acetyl L-Cysteine compulsive behavior study.

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Nattokinase for Hypertension

2009-07-07T01:16:00.000-07:00

Eighty-six patients with prehypertension or stage 1 hypertension were randomly assigned to receive 1 capsule per day of nattokinase or placebo for 8 weeks. Compared with placebo, nattokinase significantly decreased mean systolic and diastolic blood pressure.

View Nattokinase for Hypertension further details.

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Quercetin Increases Endurance without Regular Exercise Training

2009-06-28T23:07:00.000-07:00

A study by researchers at the University of South Carolina’s Arnold School of Public Health shows that quercetin, the powerful antioxidant/anti-inflammatory compound found in fruits and vegetables significantly boosts endurance capacity and maximal oxygen capacity (VO2max) in healthy, active but untrained men and women.

The fatigue-fighting and health properties of quercetin – found in the skins of red apples, red onions, berries and grapes – have implications not only for athletes and soldiers whose energy and performance are tested to the extreme, but also for average adults who battle fatigue and stress daily.

View details of this quercetin increases endurance study.

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Antibiotics Take Toll on Beneficial Microbes in Gut

2009-06-24T00:48:00.000-07:00

In studies in mice, University of Michigan scientists have shown that two different types of antibiotics can cause moderate to wide-ranging changes in the ranks of probiotic bacteria in the gut. In the case of one of the antibiotics, the armada of “good bacteria” did not recover its former diversity even many weeks after a course of antibiotics was over.

"The study results suggest that unless medical research discovers how to protect or revitalize the gut microbial community, “we may be doing long-term damage to our close friends.”

View details on this antibiotic probiotic gut microbe study.

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Green Tea Extract Shows Promise in Leukemia Trials

2009-06-17T23:39:00.000-07:00

Mayo Clinic researchers are reporting positive results in early leukemia clinical trials using the chemical epigallocatechin gallate (EGCG), an active ingredient in green tea. The trial determined that patients with chronic lymphocytic leukemia (CLL) can tolerate the chemical fairly well when high doses are administered in capsule form and that lymphocyte count was reduced in one-third of participants.

The majority of individuals who entered the study with enlarged lymph nodes saw a 50 percent or greater decline in their lymph node size.

View details on this green tea leukemia study.

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Vitamin D3 May Halt Lung Function Decline in Asthma and COPD

2009-05-27T23:32:00.000-07:00

Vitamin D may slow the progressive decline in the ability to breathe that can occur in people with asthma as a result of human airway smooth muscle (HASM) proliferation, according to researchers at the University of Pennsylvania.

The group found that calcitriol, a form of vitamin D, naturally synthesized within the body, reduced growth-factor-induced HASM proliferation in cells isolated from both persons with asthma and from persons without the disease. The proliferation is a part of process called airway remodeling, which occurs in many people with asthma, and leads to reduced lung function over time.

Read more about vitamin D halts asthma and COPD

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DHEA Hormone Replacement Increases Bone Density in Older Women

2009-05-16T20:13:00.000-07:00

Taking a DHEA supplement combined with vitamin D and calcium can significantly improve spinal bone density in older women, according to a new study from a Saint Louis University scientist and his colleagues at Washington University.

The results of the study are promising for older women. According to Weiss, patients who achieve similar increases of 2 to 4 percent in spinal bone density with the help of medication experience a 30 to 50 percent reduction in risk of spine fractures.

Read details on this dhea bone mineral density study.

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Folic Acid May Help Treat Allergies, Asthma

2009-05-09T22:59:00.000-07:00

Folic acid, or vitamin B9, essential for red blood cell health and long known to reduce the risk of spinal birth defects, may also suppress allergic reactions and lessen the severity of allergy and asthma symptoms, according to new research from the Johns Hopkins Children’s Center.

“Our findings are a clear indication that folic acid may indeed help regulate immune response to allergens, and may reduce allergy and asthma symptoms,” says lead investigator Elizabeth Matsui, M.D.

Read details on this folic acid allergy and asthma study.

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Oral Vitamin D May Help Prevent Atopic Dermititis

2009-03-24T20:36:00.000-07:00

A study suggests that use of oral Vitamin D supplements bolsters production of a protective chemical normally found in the skin, and may help prevent skin infections that are a common result of atopic dermatitis, the most common form of eczema.

Atopic dermatitis is characterized by areas of severe itching, redness and scaling. Over time, chronic changes can occur due to constant scratching and rubbing. The condition puts patients at increased risk for skin infections by Staph aureus and the herpes and small pox viruses.

Read details on this vitamin D-3 atopic dermititis study.

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Omega-3 Fatty Acids Keep Arteries Healthy

2009-03-15T23:05:00.000-07:00

Fish are generally rich in omega-3 fatty acids, which have shown benefit in many health areas such as helping to prevent mental illness and delaying some of the disabilities associated with aging.

Researchers found that a diet rich in fish oils can prevent the accumulation of fat in the aorta, the main artery leaving the heart. They found that the fatty acids contained in fish oil markedly inhibit the entry of “bad,” or LDL, cholesterol into arteries and, as a result, much less cholesterol collects in these vessels.

Read more on this omega-3 fatty acid artery study.

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Mediterranean Diet Associated With Lower Risk of Cognitive Impairment

2009-02-16T20:48:00.000-08:00

Eating a Mediterranean diet appears to be associated with less risk of mild cognitive impairment—a stage between normal aging and dementia—or of transitioning from mild cognitive impairment into Alzheimer’s disease.

Previous studies have shown a lower risk for Alzheimer’s disease among those who eat a Mediterranean diet, characterized by high intakes of fish, vegetables, legumes, fruits, cereals and unsaturated fatty acids, low intakes of dairy products, meat and saturated fats and moderate alcohol consumption.

The Mediterranean diet may improve cholesterol levels, blood sugar levels and blood vessel health overall, or reduce inflammation, all of which have been associated with mild cognitive impairment. Individual food components of the diet also may have an influence on cognitive risk. For example, potentially beneficial effects for mild cognitive impairment or mild cognitive impairment conversion to Alzheimer’s disease have been reported for alcohol, fish, polyunsaturated fatty acids (also for age-related cognitive decline) and lower levels of saturated fatty acids.

Read details on this mediterranean diet cognitive impairment study.

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Vitamin D Tied to Muscle Power in Adolescent Girls

2009-02-08T00:52:00.000-08:00

Vitamin D is positively related to muscle power, force, velocity and jump height in adolescent girls.

Vitamin D affects the various ways muscles work and we’ve seen from this study that there may be no visible symptoms of vitamin D deficiency,” said Dr. Ward.

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Diabetes Increases Risk for Alzheimer’s Disease and Dementia

2009-01-31T23:42:00.000-08:00

Diabetics have a significantly greater risk of dementia, both Alzheimer’s disease — the most common form of dementia — and other dementia.

Researchers from Sweden show that getting diabetes before the age of 65 corresponds to a 125 percent increased risk for Alzheimer’s disease. This risk of Alzheimer’s disease or other dementia was significant for mid-life diabetics — as opposed to those who develop diabetes after 65.

Read details on this diabetes Alzheimer's dimentia study.

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Resveratrol May Protect Against Alcoholic Fatty Liver Disease

2009-01-24T14:53:00.000-08:00

Researchers reported a protective effect for resveratrol against alcoholic fatty liver disease in mice.

Laboratory research has associated alcoholic fatty liver with the inhibition of two signaling molecules, SIRT1 and AMPK, which regulate the liver’s fat metabolism pathways. Dr. Min You and colleagues fed mice low-fat diets supplemented with or without ethanol (alcohol) and/or a low or high dose of resveratrol, and measured the expression of SIRT1 and AMPK in the animals’ livers. They confirmed that resveratrol activated SIRT1 and AMPK in the mice that received alcohol, which prevented fatty liver.

See the resveratrol alcoholic fatty liver disease article citation.

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Researchers Link Blood Sugar to Normal Cognitive Aging

2009-01-19T23:13:00.000-08:00

Senior moments are a normal part of aging. Such lapses in memory, according to this new research, could be blamed, at least in part, on rising blood glucose levels as we age. The findings suggest that exercising to improve blood sugar levels could be a way for some people to stave off the normal cognitive decline that comes with age.

Previously, using high-resolution brain imaging, Dr. Small and his colleagues discovered that decreasing brain function in one area of the hippocampus, called the dentate gyrus, is a main contributor of normal decline in memory as we age. Showing for the first time that blood glucose selectively targets the dentate gyrus is not only our most conclusive finding, but it is the most important for 'normal' aging- that is hippocampal dysfunction that occurs in the absence of any disease states.

Read details on this blood sugar link to cognitive decline.

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High insulin levels raise risk of breast cancer in postmenopausal women

2009-01-13T01:52:00.000-08:00

Higher-than-normal levels of insulin place postmenopausal women at 50% increased risk of breast cancer, researchers at Albert Einstein College of Medicine. Their findings suggest that interventions that target insulin and its signaling pathways may decrease breast cancer risk in these women.

Women with the highest insulin levels in their blood were more than two times more likely to develop breast cancer than women with the lowest insulin levels.

Read about this insulin breast cancer study.

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Grape Seed Extract Kills Laboratory Leukemia Cells

2009-01-08T00:34:00.000-08:00

An extract from grape seeds forces laboratory leukemia cells to commit cell suicide, according to researchers from the University of Kentucky. They found that within 24 hours, 76 percent of leukemia cells had died after being exposed to the extract.

While grape seed extract has shown activity in a number of laboratory cancer cell lines, including skin, breast, colon, lung, stomach and prostate cancers, no one had tested the extract in hematological cancers. Hematological cancers – leukemia, lymphoma and myeloma – accounted for an estimated 118,310 new cancer cases and almost 54,000 deaths in 2006, ranking these cancers as the fourth leading cause of cancer incidence and death in the U.S.

Read details on this grape seed extract leukemia study.

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Probiotics Stop Antibiotic-Caused Diarrhea

2008-12-26T17:38:00.000-08:00

Up to one in five people on antibiotics stop taking their full course of antibiotic therapy due to diarrhea. Physicians could help patients avoid this problem by prescribing probiotics.

Antibiotics target “bad” bacteria but may also kill the “good” bacteria in the large intestine, leading to diarrhea. Diarrhea can also result from bacterial and viral infections. Probiotics - cultures of “good” microorganisms similar to those normally found in the gut ─ have been promoted as restoring the microbial balance disrupted by antibiotics and infections.

“With the level of evidence that probiotics work and the large safety margins for them, we see no good reason not to prescribe probiotics when prescribing antibiotics," reports the study.

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Selenium may prevent high risk-bladder cancer

2008-12-10T00:21:00.000-08:00

A study published in the December issue of Cancer Prevention Research, a journal of the American Association for Cancer Research, suggests that selenium, a trace mineral found in grains, nuts and meats, may aid in the prevention of high-risk bladder cancer.

Findings showed an inverse association between selenium and bladder cancer among women, some smokers and those with p53 positive bladder cancer.

View details on this selenium bladder cancer study.

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Study Details Annual Medical Cost Increases For People with Diabetes

2008-11-29T00:55:00.000-08:00

People diagnosed with diabetes spend over $4,100 more each year on medical costs than people who don’t have diabetes, a gap that increases substantially each year following the initial diagnosis.

Researchers calculated that a 50-year-old newly diagnosed with diabetes spends $4,174 more on medical care per year than a person the same age who doesn’t have diabetes. For the person with diabetes, medical costs go up an additional $158 per year every year thereafter, over and above the amount they would increase due to aging-related increases in medical expenses.

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Low Potassium Linked to High Blood Pressure

2008-11-27T00:06:00.000-08:00

As a risk factor for high blood pressure, low levels of potassium in the diet may be as important as high levels of sodium—especially among African Americans.

The new study suggests that low potassium may be a particularly important contributor to high blood pressure among African Americans, and also identifies a gene that may influence potassium's effects on blood pressure.

High-potassium foods include fruits such as bananas and citrus fruits and vegetables.

Read more about this low potassium - high blood pressure study.

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Children double use of diabetes drugs

2008-11-05T22:13:00.000-08:00

America’s children more than doubled their use of type 2 diabetes medications between 2002 and 2005, with girls between 10 and 14 years of age showing a 166 percent increase. One likely cause: Obesity, which is closely associated with type 2 diabetes.

In addition to diabetes, the study found that utilization patterns for blood pressure, cholesterol, attention-deficit disorder and attention-deficit/hyperactivity disorder (ADD/ADHD), asthma and depression medications increased at varying levels during the four year period.

Read details on children's double use of diabetic and other drugs.

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Cost of Diabetes Treatment Nearly Doubled Since 2001

2008-11-01T22:48:00.000-07:00

Because of the increased number of patients, growing reliance on multiple medications and the shift toward more expensive new medicines, the annual cost of diabetes drugs nearly doubled in only six years, rising from $6.7 billion in 2001 to $12.5 billion in 2007.

Since more then one-tenth of all health care expenditures in the United States in 2002 were attributable to diabetes, this finding raises important questions about whether the higher cost actually translates into improved care.

The average price of a diabetes drug prescription increased from $56 in 2001 to $76 in 2007, due in large part to the rapid uptake of newly available oral medications, increasingly prescribed as alternatives to injectable insulin.

Read details of this diabetes treatment cost article.

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Vitamin D Helps Prevent Skin Infections

2008-10-29T00:33:00.000-07:00

A study led by researchers at the University of California, San Diego School of Medicine suggests that use of oral Vitamin D supplements bolsters production of a protective chemical normally found in the skin, and may help prevent skin infections that are a common result of atopic dermatitis, the most common form of eczema.

Study participants were all given 4000 IUs of oral Vitamin D3 (cholecalciferol) per day for 21 days. Skin lesions were biopsied before and after the 21-day period. The researchers found that oral vitamin D use by the patients appeared to correct the skin’s defect in cathelicidin. “These results suggest that supplementation with oral vitamin D dramatically induces cathelicidin production in the skin of patients with atopic dermatitis,” said Hata. “It also slightly elevated its production in normal skin in this study.”

Read details on this vitamin D skin infection study.

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Vitamin D Deficiency May Be More Common in Parkinson’s Disease Patients

2008-10-26T23:07:00.000-07:00

Individuals with Parkinson’s disease appear more likely to be vitamin D deficient than healthy adults of the same age or patients with Alzheimer’s disease, according to a report in the October issue of Archives of Neurology, one of the JAMA/Archives journals.

Significantly more patients with Parkinson’s disease (55 percent) had insufficient vitamin D than did controls (36 percent) or patients with Alzheimer’s disease (41 percent),” the authors wrote.

Read details on this Vitamin D Parkinson's Disease study.

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